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Forty RCTs were selected from a systematic review conducted by Notley et al.,335, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377, 378, 379, 380, 381, 382, 383, 384, 385, 386, 387, 388, 389, 390, 391, 392, 393, 394, 395 and nine additional RCTs were identified to reflect updated evidence.396, 397, 398, 399, 400, 401, 402, 403, 404 Subgroup analyses of the general adult population and pregnant smokers were performed

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